Butterbear Half bear and half butterfly, Butterbear is mostly bear in appearance. She has yellow fur with a white tummy, small wings, and short antennae with flowers on their ends. She is a keen gardener who is gentle & patient despite the crazy adventures of her friends.

Eleroo Half elephant and half kangaroo. One of the larger Wuzzles, Eleroo is purple, with the body shape and tail of a kangaroo and an elephant's trunk and ears. He has a horizontally striped pouch (despite the fact that pouches are found only on female kangaroos).

Moosel Half moose, half harp seal. Moosel is a small Wuzzle with the antlers and snout of a moose and he has flippers at the most bottom of his body. Moosel has a vivid imagination, which makes him believe in monsters. He is often annoyed by Rhinokey, sarcastically saying to him in an episode "You're a million laughs, Rhinokey."

Hoppopotamus Half rabbit, half hippopotamus. Hoppo, as she is called by her friends, is a Wuzzle who is a hippopotamus complete with a rabbit's ears, buck teeth, and cotton tail. She loves to sing and act. Hoppo is a pushy demanding diva, her often pushing the others around or aside, but she can be sweet. Hoppo has a crush on Bumblelion, but Bumblelion has his heart set on Butterbear, which makes Hoppo furious and dissatisfied. Despite the fact that she is part hippo, she is as dainty as a gazelle. Like Moosel, she is often annoyed by Rhinokey and she always tries to get away from him.

Rhinokey Half rhinoceros and half monkey. Rhinokey is a Wuzzle who has a rhino-like snout with a horizontal-stripped horn, pink fur, and rhino-like legs. He is in a posture that is very much like a monkey's. Rhinokey is a fun-loving happy-go-lucky prankster. He loves to play practical jokes. He can be obnoxious, but is still loyal to his friends. Rhinokey is best friends with Bumblelion and (in Rhinokey's opinion) Moosel.

Tycoon Half Tiger and half Raccoon. Tycoon is the rich kid of Wuz. He owns a money tree.

Croc Half crocodile, half dinosaur; The main villain of the show. He can be referred to as either "king Croc", "Crocasaurous", or just simply Croc (also, his name is not spelled "Crock" with a k). Croc is a no-good ignoramus and does anything to get what he wants. He always wants the best of what the Wuzzles have.

Brat Half boar, half rat, Croc's sidekick. Brat sputters and babbles and grunts in his speech, but Croc understands what he is saying. He's kind of like Taz from Looney Tunes.

Flizard Half frog, half lizard, Croc's other sidekick. Flizard is lacking in intelligence, but loyal to Croc.